| |
SYNTHESIS SERVICES
InB:Hauser's synthetic team makes milligram to multi-kilogram quantities of development candidates, synthetic intermediates and APIs for pre-clinical R&D, all phases of clinical trials and commercial use. InB:Hauser has a proven track record in assisting clients with problem-solving expertise well beyond the initial drug discovery stage.
Services
- Lead Optimization
- Complete analytical support
- Synthetic route development
- Purification method development
- Process research and development
- Process scale-up / optimization
- Manufacturing from mg to 100 kg scale
- Custom manufacturing cGMP
Capabilities
- Total synthesis of natural products and derivatives
- Synthesis of cGMP drug intermediates and active pharmaceutical ingredients (APIs)
- Total and semi-synthesis of bioactive compounds
- Standards for bioactivity, ADME, stability and degradation studies
- cGMP materials for clinical trials
With over 30 years of experience, InB:Hauser is a world leader in the extraction, isolation, purification and synthetic modification of natural products from plant, marine, and microbial sources (semi-synthesis).
Examples of Compounds Synthesized
- Over 200 derivatives of paclitaxel and other cytotoxic taxanes
- Teracycline antitumor agents
- Dopamine pathway agonists / antagonists
- Immuno-modulators (peptides small molecules)
- Allosteric modifiers (non-chiral small molecules)
- Artemisinin derivatives
- Cyclooxygenase inhibitors (non-chiral small molecules)
- Naturally derived conjugates
- Over 100 derivatives of the antimalarial natural products, camptothecin and artemisinin
- Polymeric based drugs
- Protein-linker-metal ligands
- Advanced intermediates
- Vitamin D derivatives
InB:Hauser has successfully taken numerous multi-step synthetic processes from the bench (mg scale) through process development to pilot (multi-kilogram scale 20-200L glassware) manufacturing.
Clients working with InB:Hauser have direct contact with an experienced staff of professionals who are committed to providing high quality and cost-effective product development services.
Return to Top
|
